​​​      For The NB Protocol  click on the "NB Protocol" page


*the information compiled in this website are the research and conclusions of Don Mau.


Treating Bartonella and associated diseases;


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The information presented on this website is an account of my own experience healing myself and my conclusions of my own research. I am not a Doctor. This account is for information purposes only.


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This information is about taking advantage of a common theme in nature to make chronic "Lyme" and associated disease treatment effective,that theme is synergy. The protocol works for LYME disease, Morgellons disease and the variety of symptom presentations called a variety of diseases by western medicine . 
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Wilhelm "Willy" Burgdorfer Phd. is credited with the discovery of the "lyme" bacteria. Burgdorfer gained worldwide recognition for his 1982 discovery of a tick-borne spirochete as the long-sought cause of Lyme disease. However another pathogen was not seen by Dr.
Burgdorfer because it was too small to be detected by his equipment. This nanobacteria is the actual dominant pathogen in Lyme disease and is approximately 300x smaller than the borrelia spirochete, it is the genus Bartonella. Bartonella is one of only two bacteria known to science to be able to transfer DNA into the human cellular genome.

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Morgellons as a symptom presentation of "lyme" disease is caused by a gene expression of Bartonella infection that also needs a co-factor, another infection or factor that supplies DNA to create the skin fibrosis. Other co-infections a person has also form a symbiosis with the MD bacteria. So this synergistic protocol that has strategies for gram negative, gram positive bacteria, fungi, viruses and parasites also deals with the MD bacteria. Another factor that is an obstacle to treatment with Bartonella and MD infections are the internal angiogenic tumors that are produced , this is discussed indepth on the "Bartonella" page. The biggest reason treatment of these types of infections fail is nanobacterial calcification. Morgellons is essentially skin fibrosis.

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http://www.pnas.org/content/95/14/8274.full

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"Nanobacteria: An alternative mechanism for pathogenic intra- and extracellular calcification and stone formation"

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"nanobacteria fall within the α-2 subgroup of Proteobacteria, which also includes Brucella and Bartonella species (10). The latter genera include human and animal pathogens that share similarities with nanobacteria, e.g., some antigens (our unpublished data), intra- and extracellular location in the host, and cytopathic effects"

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Morgellons as a symptom set is the result of altered human DNA. This trangenic DNA insertion causes the tumor growth that is found under lesions that don't heal and other locations in the body. MD sufferers also experience disfigurement from tumor growth under the skin. Agrobacterium is used extensively in genetic modification and has been implicated in MD. Agrobacterium is a bacteria from the Rhizobiales bacterial order. Bartonella is also a bacteria from the Rhizobiales order and shares very similar characteristics. Agrobacterium is the gene transfer method of choice in genetic engineering because it was thought to be the only bacteria capable of DNA transfer into eukaryotic cells, cells with a nucleus or mammalian cells.  This causes a genetically induced disease. Bartonella also transfer DNA into eukaryotic cells. MD is not just a skin disorder, it affects every part of a persons body.

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http://www.pnas.org/content/108/35/14643.abstract

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"Conjugative DNA transfer into human cells by the VirB/VirD4 type IV secretion system of the bacterial pathogen Bartonella henselae."

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microbewiki.kenyon.edu/index.php/Bartonella_henselae

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"Bartonella are the only bacteria able to produce angiogenic tumors in humans, very much like the Agrobacterium species that produce tumors in plants"


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https://www.youtube.com/watch?v=Sz9e-is-UuY


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The above are very good comments from Dr. Edward Breitschwerdt at NorVect 2014.


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http://www.nutritionalhealthnow.com/bartonella-a-stealth-infection/


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"Bartonella is commonly found with other infections such as Borrelia burgdorferi (Lyme disease) and is often referred to as a co-infection.  What most people don’t know is that Bartonella actually suppresses Lyme disease and becomes the primary infection."


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As has been demonstrated by the Lyme community and Morgellons community these Bartonella and MD infections are very hard to remove. This is because the infection becomes sequestered in genetically induced tumors and calcified plaque.  Standard antibiotics are very ineffective at killing the Bart/ MD pathogens much less attacking the contents of these tumors. 

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​The combination of herbs used in the protocol are used to treat the vascular system and many tissues and to support the organs but herbal protocols alone are inadequate .When reviewing a very good research paper by Michael McIntyre titled “Synergy a Key Herbal Concept” then the concepts of "pharmacodynamic and pharmacokenetic synergy are understood.

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http://anh-europe.org/files/Michael_McIntyre_Synergy_in_1000_words.pdf


  “Polypharmacy” is common in herbal medicine and is the combining of several herbs in one combination that acts synergistically more powerful.There is “pharmacodynamic” synergy which is two or more medicinally active phytochemicals acting together on a single weakness and there is “pharmacokinetic” synergy when one phytochemical changes part of the infective pathogen’s defenses to make another phytochemical more effective. My thought to expand the practical limits of this synergy was reinforced.

​When you take into account that there are a collection of infections inside a person that are causing this “Chronic Lyme” and it many symptom sets then what is happening is pathogenic synergy. Pathogenic synergy is a commonly occurring phenomenon in nature and can be demonstrated by the phenomenon of “colony collapse disorder”, this is where whole colonies of bees die. What is happening there is that a parasite called Varroa Destructor changes the internal host immune system dynamic so the deformed wing virus can take over. That would be an example of kinetic synergy.There are numerous examples of pathogenic synergy in the scientific literature. Pathogenic synergy is common in humans as well.

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​Currently it is agreed by all the top researchers and doctors that current testing is inadequate. The evidence would suggest that available testing should be rated less than inadequate because the possible variety of infections that a person is subjected to and that accumulate in the body are for a great extent not tested for or not detected.I know many people will disagree with the conclusions I came to about testing for infections, but I came to these conclusions to put my own needs in perspective and still believe them wholeheartedly.
Since a “clinical” diagnosis is given by " LLMD’s" using only the tests to reinforce such a diagnosis and that since the tests were too inadequate to tell that without a doubt a person is clear of various infections they are somewhat irrelevant.


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http://www.klinghardtacademy.com/Protocols/Lyme-Disease.html


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"In the last decade the majority of outcome-oriented physicians observed a major shift: we realized that it was neither the lack of vitamins nor growth hormone that made our patients ill. We discovered that toxicity and chronic infections were most often at the core of the client’s suffering. We watched the discussion on which infection may be the primary one: mycoplasma, stealth viruses, HHV-6, trichomonas, Chlamydia pneumoniae, leptospirosis, mutated strep, or what else?

The new kid on the block is Borrelia burgdorferi (Bb), and some of us have looked at it for a long time as possibly being the bug that opens the door for all the other infections to enter the system.  Lyme disease has become a buzz word in the alternative medical field. Since none of the recommended treatments are specific to either one of the microbes, we can never assume that we really know what we treated once a patient has recovered."


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​The pathogens that a person may become infected with are bacteria, fungi, viruses, parasitic organisms, and mycoplasma and are often thought of as simple creatures not capable of advanced systems of survival. Brucella, Agrobacterium and Bartonella and Mycoplasma, are the disease factors that are most concerning. Their survival systems are quite advanced. There are also pleomorphic forms and biofilms to consider. The Biofilms become calcified. Ag and Bartonella make tumors that become calcified. Researchers spend time looking at blood plasma , they should also be doing heart and spinal cord biopsies looking for endothelial tumor growth.

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​The pathogenic synergy increases the virulence of the collection of infections. The collective pathogens readily share information by "quorum sensing' and exchanging DNA to share resistance.Essentially the collection of infections form a symbiotic relationship resulting in pathogenic synergy that is commonly called virulence. The pathogens work as a team so they must be treated as a unit. Another reason that they should be treated as a single infection with many components is that the pathogenic DNA can cause re-infection. DNA is the genetic material that when combined with nutrients will generate life.

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In order to prepare someone for actual treatment of the infections a good course of action is to maximize detox potential and support organ function.When pathogens are inside a person they release exotoxins and those toxins are responsible for symptoms. When they are killed the pathogens release a flood of endotoxins and those are responsible for the symptoms people experience in a Herxheimer reaction. The symptoms of the Herx are directly related to the symptoms of the particular type of infection. Those toxins need to be detoxed to return to health because they are very detrimental to health themselves.I suggest the following to prepare the body for treatment.


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It is also very important to understand the role of Histamine. Histamine is often associated with "Allergies", Histamine is an immune system component. When cells are damaged from a bacterial die off that release endotoxins then those damaged cells release Histamine. Histamine causes the surrounding tissue to become permeated, to get microscopic holes, so that the tissue can better detox the harmful endotoxins (LPS), the LPS traveling through these holes cause inflammation because of it's acidity, that is often seen as redness in "allergies". When a person is experiencing skin issues from treatment it is a sign that the treatment is working and becoming alarmed at this and stopping treatment or lowering doses is the wrong decision. Allergy medications or Anti-Histamines that are prescribed for "Allergy" symptoms actually make the cause of the problem worse by keeping more of the caustic toxins inside a person. Skin issues during treatment are a welcome sign that the treatment is working. The vast majority of people diagnosed with "allergies" actually have an internal bioterrain toxicity issue that is more than likely attributable to some kind of chronic infection combined with dysfunctional detox pathways. If you use a search engine and put in "detox" and "allergies" many enlightening sources of information will come up.

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Why not antibiotics?, you might ask. The reason that pharmaceuticals are identified as toxins in the body is that they are synthetic chemical isolates. They are not naturally occurring substances in the body or any organism. All organisms are essentially made of the same building blocks or molecular structures, just rearranged to make a person, a wolf or a rose. The medicinal ingredients in the herbs work against these pathogens because they are the plant’s natural defense systems against the same types of pathogens.In the rain forest where it is warm and moist that is a good environment for these types of pathogens to grow. Not all medicinal plant tinctures come from the rainforest, some of them are made from the roots of the plant. The root is in the soil where pathogens also thrive. That's why these plants have these kinds of defense systems.Plants have natural defense systems that are extremely sophisticated and complex and science doesn’t have the capacity to understand all the intricacies of their function. Medicinal plants can have 1,000 or more different phytochemicals inside each plant. These phytochemicals naturally occur in an organism and the historically used medicinal plants are compatible with organisms like Lyme patients. Synthetic chemical isolates do not occur in nature and cause a burden to the body because they are toxins. This is also why medicinal plants have few or no side effects. The tinctures used are organic and will be easily metabolized and processed in your body. Synthetic ABX toxins can stay in the fat cells for life if not properly detoxed. As well the synthetic antibiotic use has been determined by various researchers to not only kill the targeted bad bacteria but also much of the good bacteria in your body, disrupt hormone function perhaps permanently and they scramble your DNA, since your DNA controls new cell growth this is not conducive to health.

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Another reason not to use antibiotics is that they are synthetic chemical isolates. They are extremely stable molecules and don't break down easily, then they enter the environment through the sewage system and do the same thing the bacterial balance there that they do in the G.I. tract.

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http://www.sciencedirect.com/science/article/pii/S0025326X04003881

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"Ecosystem response to antibiotics entering the aquatic environment."


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The "biofilms" that are causing difficulty in treating "lyme" disease are not standard biofilms ,they are calcification clusters and are being grouped in with standard biofilms.

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Some would suggest that supporting your organs and getting good nutrition will help your immune system to rally against the infection however these infections infect the immune system and have complex ways of avoiding your immune system so you need to introduce an artificial immune system that goes deep into tissues. The artificial immune system must also have enough tools to fight the pathogenic synergy that is chronic Lyme. It also has to be non toxic because treatment duration is lengthy, I suggest 1 year.

The pathogens actively shut down the immune system by infecting the various immune system cells and creating protein decoys. This reality lead me to understand the need for an artificial immune system.


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Diet-You should also check your food purchases to eliminate refined sugar from your diet. Juicing is very popular but it breaks down the natural fiber in fruit. That natural fiber causes a slow release of the natural sugars in fruit. Juicing of fruit should be avoided because it creates a sugar surge which upsets hormone levels. Caffeine promotes adrenal fatigue. Alcohol in excess is bad for the liver. Eat as much of an organic diet as possible, especially avoid meats that have synthetic antibiotics and hormones as well as nitrate preservatives. The idea that you are going to "starve" the microbes by taking something out of your diet that you need is a flawed approach. If you eat anything they want to feed on while using the protocol you will likely experience a die off reaction because that food item and nutritional component is just like the cheese in a mouse trap.

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The length of treatment is long because these infections get everywhere in the body including the bone marrow.

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This protocol removes infections over time. If you try to remove them too fast you will hurt yourself. If herxing has gone away or is minimal then it is time to raise the dose slightly. If it is overwhelming lower the dosing and use the tools discussed in the Cytokine cascade comments. This protocol will show just how infected a person can become by killing all pathogen types. The timing of all the ingredients in the protocol is to this end, to remove the infections and herx in a managed way.


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It is very important that you hydrate with WATER while using this protocol, none of the items in the protocol that are liquid count toward hydration instead they tend to dehydrate and when you are dehydrated then detoxing shuts down and you can make yourself ill. If you feel the least bit thirsty or hot your already starting to get dehydrated.

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This protocol will make you herx. The “herx” is a body reaction to toxins released from the death of a pathogen. Those types of toxins are endotoxins. While the pathogens are living inside you they produce exotoxins. An exotoxin can cause damage to the host by destroying cells or disrupting normal cellular metabolism. They are highly potent and can cause major damage to the host.They can have a localized effect like the redness of an infected wound or produce systemic effects. The exotoxins of an ongoing chronic Lyme infection can cause a quickly debilitating condition or be a slow drag on the body’s attempts to keep the body well.The endotoxins are held within the pathogen and are released when the pathogen is destroyed. These are the toxins responsible for the herxheimer reaction. In holistic medicine it is sometimes called a healing crisis. This next link will help you understand the immune system so you can understand the herx better.

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Skin issues will be abundant in some people as toxins are moved out of the body through the skin. As well some will experience lesions and the tumor debris will be expelled there too causing a temporary but nasty looking sore. This is the healing process, it gets worse before it gets better.

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​http://www.youtube.com/watch?v=Non4MkYQpYA

If the only consideration was to kill the pathogens inside you then recovery wouldn’t be as difficult. When there is a large infection load of many types combined with chemical toxins from the environment inside you then there is a need to moderate the release of these toxins so that the body will be able to process them out without becoming very sick from that release.If you want to avoid the herxheimer reaction completely then you won’t be making progress in eliminating the infections. Some herxing is required to kill the infections inside you and the goal is to keep it at levels that are manageable and not detrimental to the body.

​ Increasing the capacity of your body to detox the endotoxins and chemical toxins, perhaps from synthetic antibiotic use, will make the process of killing the internal infections and processing those toxins out of the body more efficient and less of a healing crisis. When you are having a herxheimer reaction it can manifest in many ways depending on what you are infected with.Since the pathogens that cause certain symptoms in a particular illness cause those symptoms because of what the pathogens carry then killing that pathogen and releasing those endotoxins will exhibit similar symptoms. This is a way to determine what type of infections you carry to some degree. Although when using this protocol, which carries a philosophy of treating for all pathogen types, the symptoms could be so varied and wide spread that the conclusion could be that you were infected with a lot of different microbes. That was the case with me. There were definite symptoms relating to particular infection types but also many unanticipated herxheimer symptoms that caused me to invest a good amount of time thinking about what was actually happening to me.

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Your natural immune system just gets very dysfunctional from these infections. The white blood cells , Natural Killer cells, t-cells and b-cells , get infected. The bone marrow where they are produced is infected, the thymus where t- cells mature is infected, The lymph system is infected. They take away your defenses.
 When white blood cells respond to a chronic systemic infection something that they do is to release endogenous pyrogens. EP's are hormones that signal the hypothalamus to regulate body temp by creating fever or chills.
If you start getting chills after you have been using treatment for some time it is a sign that your immune system is recovering.
​Another sign that your immune system is recovering is the itching. The itching is caused by histamine released by damaged cells. The histamine release makes surrounding tissue more permeable and is an attempt by your body to increase detoxing through the skin. So when your immune system recovers enough to be functional itching will increase because the pathogen and immune system war is creating a lot of damaged cells.


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​The herxheimer reaction or “acute inflammatory response” typically raises , heart rate and blood pressure and particular accompanying symptoms will depend on the source of the endotoxin. I spent approximately 3 months in a constant daily herx and about another 2 months in fading waves of herxing after arriving at the point when I was fully engaged in the protocol at full dose. Out of all the many numerous symptoms I had I could always attribute them the endotoxin release and never found the symptoms to be directly caused by the protocol. This was proven out because I continued steady usage and dosing and those symptoms left when the endotoxins were detoxed.*

The timeframes for an individuals recovery are governed by many variables and the herx timeframes as well. It depends on what you are infected with and there are many strains of each microbe. It also depends how loaded up with biofilms the body is and how long you have been infected.Your personal experience with the herxheimer reaction will depend on how infected you are and how efficiently you are detoxing. Your progress and time frames are dependent upon those variables.

​The dosing recommended should be considered in the context of your own situation. It’s a good thing to drink lots of water in order to flush these toxins out of your system.   A popular rule of thumb is to drink half your body weight in ounces of water daily. I did spend a few days in bed during that time but it was because the herx was an indication of effectively killing a lot of pathogens and that my body was telling me it needed to recover.


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When doctors talk about allergies they sometimes use the analogy that your body is like a bucket and once it is full then it overflows and you experience allergy symptoms. At one point I was talking to someone who had chronic Lyme and she told me she was allergic to the herbals. I believe this was because she was very infected and that when she tried herbal treatments it induced an almost instantaneous endotoxin release and that her detox pathways were dysfunctional so that there was a massive endotoxin release that essentially had nowhere to go. She had told me she was treating her Lyme only with nutrition and juicing so I suspect her infection level was high.

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​A herx symptom that I had was pain in the muscles and this lasted about a week initially and came back once or twice in less intensity. A lot of the herx symptoms repeated themselves several times if not more. My joints hurt and especially my knees.Something I noticed about my knees hurting was that it would only take a few days for them to feel better and each time they hurt again it felt like it was coming from a deeper area in the joint.

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​There were drenching night sweats where I would wake up soaked and had to change my t shirt so I could go back to sleep. This happened for about a week and then became less. I did have the same type of sweating around the back of my neck and on my head for a couple weeks but not like the initial phase where I would wake up in a puddle.

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​ I also had some bacterial rashes on my chin and face after shaving, making absolutely sure I had a clean razor. This is caused by the bacterial toxins and bacterial being detoxed in that area and infections being killed in the hair follicles there.The best remedy I found for the bacterial rash was to scrub the area very good with a clean mild soap and rinse with warm water a few times then the irritation would leave.
You don’t want to use a soap that is full of perfumes or chemicals. You also don’t want to use any crèmes or lotions on your skin that your body can absorb or that will clog your pores because you detox through your skin as well.There was also some redness on both of my elbows that looked like the redness you see sometimes around a wound. As the die off was taking place in my elbows the infection debris was moving out and dissipating until it was gone. I had the same type of occurrence on the sides of my neck.There were a few cysts that popped up near my knees on the skin that took about a month to heal and return to normal.The burning in my feet during the herx lasted for about 10 weeks and initially was a little painful. There were also some stinging sensations there. This is associated with a bartonella infection. I came to welcome the burn because I saw it as a sign of the treatment’s effectiveness. I noticed often that the burn would be a little more intense about an hour or two after the dosing was complete.

Prior to me becoming symptomatic in July 2011, I had some mild chest pains off and on and contributed that to job stress. I realize now I was most likely making my own job stress through the neuro-lyme. There was a period of the herx that lasted about two weeks where I was coughing up mucous almost constantly and had to keep a spittoon with me. I made an extra point of staying hydrated during that time. This was some sort of infection that seemed to focus in the bronchial area.During the herx I had headaches but they weren’t a whole head headache, they were more of a spot headache where I could feel a particular small region of the brain being acted on by the herbs. I also had toothaches and these were the kind of toothaches you would normally go to the dentist for but I waited and after the endotoxins from those regions were detoxed I felt fine there.Strangely my slightly receding hairline regrew and I attribute this to infections being removed from my endocrine system.

​ I also had some mild pain right inside my eyes and have worn glasses for about the last 10 years. I can go shopping and read the labels now without my glasses but I still use them at the computer. It’s a kind of new found freedom not having to where my glasses all the time though.I had bone pain from the herx which lasted a couple weeks and it was a welcome sign of the treatment actually penetrating the bones. It made clear to me that given time the treatment would get everywhere in my body. After the initial 2-3 months or so then I would have completely normal days only to be followed by a few days more of herxing that was progressively less intense as time went on. During the main herxing stage fever and fatigue was common. I also had liver and kidney discomfort which dissipated as that particular burst of released endotoxins was processed out of my system.Drinking a lot of water helps to alleviate the liver and kidney herx symptoms quicker. Half your body weight in ounces of water per day is a good rule.I believe some of the infection being killed was right inside my liver and kidneys and that came as the most intense discomfort in the first couple of weeks after being on the whole protocol. Had there been any actual hepatoxicity or kidney toxicity then the discomfort would have intensified because I did not reduce the dosage or frequency of dosing.

​ There was some anxiety as to what was happening to me but I was always able to associate it with making progress in eliminating the infections and that gave me the inspiration to stay the course.I had thought about reducing the dosage a couple of times but in those cases my more intense herx symptoms subsided by the next dosing time so I never did.Some sources may suggest limiting your gluten intake because gluten turns to glucose in your body and that is supposed to feed the infections. I actually ate a lot of wheat and rye breads but bought good organic ones without sugar in the recipe.Eating fruit is fine and healthy, it is a great detoxer. Blueberries neutralize neurotoxins. Fruit has natural fiber in it that slows the release of fructose and glucose so there isn't a surge of hormones just don't juice the fruit.Gluten is the energy for your body and unless you are confident that you are allergic I think it is fine and even helpful to eat because of the sterols and lipids in clean grains. Lipids and sterols ,which are good fats, will work to revitalize your cells.Something that occurred during the herx about 10 weeks in is the annoying crawling feeling that I had on my skin off and on completely and finally disappeared. Some sources suggest this may be neuropathy but I believe it could also be from an infection of the hair follicles or pores.


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In my own case I had Multiple Chemical Sensitivity during my illness and couldn't process any smells of chemicals, even minor chemical smells would result in nose irritation for hours. After doing this protocol my MCS symptoms are gone..


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~d