To penetrate tissues , joints and bones small molecule treatments are needed. The other side of the equation is the die off toxins, LPS. Lipopolysaccharides are Large molecules and because of this the die off toxins don't readily detox well. LPS are also very stable molecules and are not affected by PH or temperature. This next section will give you some tools to help deal with these die off toxins which have the most disconcerting affect on your Herxheimer reaction.


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It is very important that you hydrate with WATER while using this protocol, none of the items in the protocol that are liquid count toward hydration instead they tend to dehydrate and when you are dehydrated then detoxing shuts down and you can make yourself ill. Please review this link to give some more information on why hydration is so important especially when using this protocol. If you feel the least bit thirsty or hot your already starting to get dehydrated.


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The protocol is designed to remove infections over time. Bartonella is the most serious of the infections and when it is killed the cell walls release endotoxins. These endotoxins are LPS, lipopolysaccharides, they contain toxic lipids which will damage DNA and tissues. These LPS are highly acidic and trying to push this protocol faster with bigger doses can only be the decision of someone who doesn't understand what is taking place. The resulting endotoxin release from that approach could be compared to drinking diluted paint remover.


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​DRINKING A GLASS OF WATER WITH A TEASPOON OF COMMON HOUSEHOLD BAKING SODA TWICE A DAY IS RECOMMENDED TO NEUTRALIZE THESE ENDOTOXINS- however you should not exceed two teaspoons daily because this will have an adverse effect on digestion.


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The Lipids that are built into the protocol do many things, these are the Mega PC35, which is a concentrated version of 35% PC (phosphatidylcholine), and the Cod liver oil. They also help to ease the herx and to protect the heart during the die off you will experience there.

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This protocol will make you herx. The “herx” is a body reaction to toxins released from the death of a pathogen. Those types of toxins are endotoxins. While the pathogens are living inside you they produce exotoxins. An exotoxin can cause damage to the host by destroying cells or disrupting normal cellular metabolism. They are highly potent and can cause major damage to the host.They can have a localized effect like the redness of an infected wound or produce systemic effects. The exotoxins of an ongoing chronic Lyme infection can cause a quickly debilitating condition or be a slow drag on the body’s attempts to keep the body well.The endotoxins are held within the pathogen and are released when the pathogen is destroyed. These are the toxins responsible for the herxheimer reaction. In holistic medicine it is sometimes called a healing crisis. 

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This next link will help you understand the immune system so you can understand the herx better. .Skin issues will be abundant in some people as toxins are moved out of the body through the skin. As well some will experience lesions and the tumor debris will be expelled there too causing a temporary but nasty looking sore. This is the healing process, it gets worse before it gets better.

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​http://www.youtube.com/watch?v=Non4MkYQpYA



If the only consideration was to kill the pathogens inside you then recovery wouldn’t be as difficult. When there is a large infection load of many types combined with chemical toxins from the environment inside you then there is a need to moderate the release of these toxins so that the body will be able to process them out without becoming very sick from that release.If you want to avoid the herxheimer reaction completely then you won’t be making progress in eliminating the infections. Some herxing is required to kill the infections inside you and the goal is to keep it at levels that are manageable and not detrimental to the body.​ Increasing the capacity of your body to detox the endotoxins and chemical toxins, perhaps from synthetic antibiotic use, will make the process of killing the internal infections and processing those toxins out of the body more efficient and less of a healing crisis. When you are having a herxheimer reaction it can manifest in many ways depending on what you are infected with.Since the pathogens that cause certain symptoms in a particular illness cause those symptoms because of what the pathogens carry then killing that pathogen and releasing those endotoxins will exhibit similar symptoms. This is a way to determine what type of infections you carry to some degree. Although when using this protocol, which carries a philosophy of treating for all pathogen types, the symptoms could be so varied and wide spread that the conclusion could be that you were infected with a lot of different microbes. That was the case with me. There were definite symptoms relating to particular infection types but also many unanticipated herxheimer symptoms that caused me to invest a good amount of time understanding this.


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If the herx becomes too intense then there are a few things you can add to the protocol. Ginger, I have heard from a user of the protocol that Ginger tea is helpful.

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​If you are in an area where medical marijuana is available that is also effective.
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http://www.whale.to/a/human5.html
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“The Human Endocannabinoid System Meets the Inflammatory Cytokine Cascade”
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Another way to control the Cytokine cascade is Vitamin D3.


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http://www.ncbi.nlm.nih.gov/pubmed/16600924



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"Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure"


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http://www.ncbi.nlm.nih.gov/pubmed/22237768


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"Vitamin D status and cytokine levels in patients with Crohn's disease."


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I would suggest taking 10,000 I.U.'s of vitamin D3 twice daily  if you are having intense herx issues.



"Herxing" is manifested by fever, chills, headache, myalgia (muscle pain), etc. It can last for as little as a few hours or, in the case of LD and bartonellosis, months.

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Forsythia;

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http://www.ncshm.re.kr/erp/erpmenus/research_result/uploadfiles/%EC%97%B0%EA%B5%90-%EB%B0%95%EC%9A%A9%EA%B8%B0.pdf​

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Here is a source for forsythia;


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http://hawaiipharm.com/other-healthcare-products/forsythia-tincture-organic-forsythia-forsythia-suspensa-extract.html


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Green Tea extract;

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https://journal-inflammation.biomedcentral.com/articles/10.1186/1476-9255-4-1


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This is another option that actually works;


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https://www.iherb.com/pr/Gaia-Herbs-Certified-Organic-Green-Tea-Leaf-1-fl-oz-30-ml/13957